What Is VDR?

VDR is a gene which codes for a protein that acts as a receptor for vitamin D that regulates bone development and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a decreased bone mineral density among prepubescent girls of white background.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by two components, and is affected by chromosomal positions and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes possess an identifiable VDRE within their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository of data and documents relevant to legal, business, or other activities that have limitations on viewing and downloading. It uses a central computer as well as an extranet that is a restricted-access Internet connection, to allow users to login at specified times.

Companies that deal with investment bankers and in mergers and acquisitions are the most frequent users of a VDR. They must be able to share information in a transparent manner with potential investors or buyers. Due diligence processes may also require a huge amount of information. Life icloud science companies also use VDRs to store everything from clinical trials results to HIPAA documentation.